Mechanisms of formation of ionising radiation-induced chromosomal aberrations: Impact of repair pathways and nuclear architecture (Chromosome Structure)
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منابع مشابه
Pathways of DNA double-strand break repair and their impact on the prevention and formation of chromosomal aberrations.
DNA double-strand breaks (DSB) are considered the critical primary lesion in the formation of chromosomal aberrations (CA). DSB occur spontaneously during the cell cycle and are induced by a variety of exogenous agents such as ionising radiation. To combat this potentially lethal damage, two related repair pathways, namely homologous recombination (HR) and non-homologous DNA end joining (NHEJ),...
متن کاملمقایسه دزیمتری بیولوژیک با دزیمتری فیزیکی در پرتوکاران شهر بابل
Background and purpose : Ït is clearly shown that ionising radiations induce various kinds of DNÂ damages majority of which as sub-lethal damages, are repaired but still some of them are left urepaired and lead to chromosomal aberrations. These chromosomal aberrations in radiation workers, who are occupationally exposed to radiation,could be assayed with cytogenetic evaluation methods.These c...
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Background: Most of our current understanding of the biological effects of exposure to ionising radiation is based on conventional cytogenetic techniques, which enable us to determine the relationship between chromosomal aberration and dose received by radiation workers. However, conventional techniques have numerous limitations and chromosomal aberrations can be easily missed. Since FISH plays...
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تاریخ انتشار 2008